Source: MGD

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 14
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 13
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 13
IFNG P01579 interferon gamma 0.47 0.288 0.962 12
NLRP3 Q96P20 NLR family pyrin domain containing 3 8.1E-04 0.361 0.962 9
SOD1 P00441 superoxide dismutase 1 Enzyme 0.18 0.379 0.962 6
IL4 P05112 interleukin 4 4.7E-03 0.332 0.962 4
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 2
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 1
CSF2 P04141 colony stimulating factor 2 Signaling 0.83 0.330 0.962 1
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 1
ICAM1 P05362 intercellular adhesion molecule 1 3.5E-02 0.364 0.962 1
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 1
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 23
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 21
PTPN11 Q06124 protein tyrosine phosphatase non-receptor type 11 1.00 0.385 0.923 21
ATR Q13535 ATR serine/threonine kinase Kinase 3.5E-09 0.456 0.923 10
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 9
SOD2 P04179 superoxide dismutase 2 Enzyme 0.15 0.379 0.923 9
LAMC2 Q13753 laminin subunit gamma 2 Enzyme modulator 2.9E-12 0.389 0.923 8
PLAU P00749 plasminogen activator, urokinase Enzyme 2.3E-06 0.425 0.923 8
INS P01308 insulin 0.30 0.445 0.923 7
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 7
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 6