Source: LHGDN

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 226
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 169
IL6 P05231 interleukin 6 0.32 0.248 0.962 177
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 171
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 112
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 134
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 156
IFNG P01579 interferon gamma 0.47 0.288 0.962 91
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 83
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 149
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 100
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 60
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 118
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 84
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 64
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 84
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 82
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 71
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 59
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 50
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923 40
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 84
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 31
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923 65