Source: RGD

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
RFFL Q8WZ73 ring finger and FYVE like domain containing E3 ubiquitin protein ligase Enzyme 0.41 1
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 90
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 92
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 58
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 40
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 60
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 15
CRP P02741 C-reactive protein 3.7E-03 0.299 0.962 22
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 20
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 86
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 11
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 76
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 45
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 82
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 45
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 64
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 58
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 34
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 44
LEP P41159 leptin 0.46 0.349 0.846 28
CASP3 P42574 caspase 3 Enzyme 0.10 0.351 0.923 62
AR P10275 androgen receptor Nuclear receptor 0.99 0.351 0.846 12
NFE2L2 Q16236 nuclear factor, erythroid 2 like 2 Enzyme 3.6E-03 0.357 0.885 23
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 27