Source: HPO

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
ZFHX2 Q9C0A1 zinc finger homeobox 2 0.99 1
TP53 P04637 tumor protein p53 transcription factor 0.17 0.251 0.897 114
IL6 P05231 interleukin 6 0.34 0.287 0.966 11
BCL2 P10415 BCL2, apoptosis regulator signaling molecule 0.57 0.312 0.862 7
IL10 P22301 interleukin 10 6.5E-03 0.320 0.931 33
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.38 0.321 0.828 34
EGFR P00533 epidermal growth factor receptor 0.50 0.325 0.862 17
PTEN P60484 phosphatase and tensin homolog hydrolase; phosphatase 0.82 0.334 0.828 243
TGFB1 P01137 transforming growth factor beta 1 signaling molecule 0.17 0.336 0.931 63
MMP9 P14780 matrix metallopeptidase 9 hydrolase; protease 7.0E-18 0.339 0.862 11
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha kinase; transferase 1.00 0.341 0.897 199
HLA-DRB1 P01911 P01912 P04229 P13760 P13761 P20039 Q29974 Q30134 Q30167 Q5Y7A7 Q95IE3 Q9GIY3 Q9TQE0 major histocompatibility complex, class II, DR beta 1 defense/immunity protein 1.0E-03 0.347 0.897 71
KRAS P01116 KRAS proto-oncogene, GTPase enzyme modulator 9.0E-04 0.350 0.724 341
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase 1.00 0.352 0.793 303
APOE P02649 apolipoprotein E 1.7E-03 0.352 0.931 50
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 1.8E-03 0.352 0.862 5
MTHFR P42898 methylenetetrahydrofolate reductase 1.2E-09 0.354 0.828 18
AKT1 P31749 AKT serine/threonine kinase 1 calcium-binding protein; kinase; transfer/carrier protein; transferase 0.98 0.355 0.862 172
IGF1 P05019 insulin like growth factor 1 0.29 0.355 0.828 59
ESR1 P03372 estrogen receptor 1 nucleic acid binding; receptor; transcription factor 1.00 0.355 0.897 26
STAT3 P40763 signal transducer and activator of transcription 3 nucleic acid binding; transcription factor 1.00 0.358 0.862 89
TLR4 O00206 toll like receptor 4 5.6E-09 0.359 0.931 33
NFKB1 P19838 nuclear factor kappa B subunit 1 1.00 0.365 0.931 31
CCND1 P24385 cyclin D1 enzyme modulator 0.90 0.365 0.828 26