Source: HPO

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 7
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 131
IL6 P05231 interleukin 6 0.32 0.248 0.962 32
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 2
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 84
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 95
IFNG P01579 interferon gamma 0.47 0.288 0.962 40
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 12
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 209
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 15
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 50
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 128
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 255
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 13
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 187
ALB P02768 albumin Transporter 0.64 0.317 0.962 21
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 49
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 254
PIK3CD O00329 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Kinase 1.00 0.319 0.885 11
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 337
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 119
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 79
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 10
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 28