Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 39
TBX3 O15119 T-box transcription factor 3 Transcription factor 0.99 0.525 0.769 4
SMARCD1 Q96GM5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 Nucleic acid binding 1.00 0.695 0.385 4
RB1 P06400 RB transcriptional corepressor 1 Nucleic acid binding 1.00 0.444 0.885 13
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 27
PIK3CB P42338 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Kinase 1.00 0.322 0.885 7
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 33
PDPK1 O15530 3-phosphoinositide dependent protein kinase 1 Kinase 0.98 0.588 0.808 4
PBRM1 Q86U86 polybromo 1 Epigenetic regulator 1.00 0.566 0.615 5
PALB2 Q86YC2 partner and localizer of BRCA2 3.0E-19 0.485 0.769 8
NOTCH2 Q04721 notch receptor 2 1.00 0.441 0.808 15
NOTCH1 P46531 notch receptor 1 1.00 0.369 0.885 16
NCOR1 O75376 nuclear receptor corepressor 1 Transcription factor 1.00 0.597 0.731 4
MAP3K13 O43283 mitogen-activated protein kinase kinase kinase 13 Kinase 0.80 0.743 0.192 4
MAP2K4 P45985 mitogen-activated protein kinase kinase 4 Kinase 1.00 0.559 0.692 9
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 33
INPP4B O15327 inositol polyphosphate-4-phosphatase type II B 0.55 0.573 0.577 4
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 29
HERC2 O95714 HECT and RLD domain containing E3 ubiquitin protein ligase 2 1.00 0.568 0.692 4
GATA3 P23771 GATA binding protein 3 0.90 0.415 0.846 4
FOXA1 P55317 forkhead box A1 Transcription factor 0.22 0.522 0.731 5
FGFR1 P11362 fibroblast growth factor receptor 1 Kinase 1.00 0.362 0.885 9
FGF4 P08620 fibroblast growth factor 4 Signaling 0.14 0.588 0.577 4
FGF3 P11487 fibroblast growth factor 3 Signaling 9.3E-05 0.505 0.808 4