Source: CGI

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923 14
BRCA2 P51587 BRCA2 DNA repair associated Nucleic acid binding 2.4E-25 0.379 0.846 16
CHEK2 O96017 checkpoint kinase 2 Kinase 1.2E-24 0.460 0.808 5
PALB2 Q86YC2 partner and localizer of BRCA2 3.0E-19 0.485 0.769 8
BRIP1 Q9BX63 BRCA1 interacting protein C-terminal helicase 1 Enzyme 6.2E-17 0.507 0.731 6
CASP8 Q14790 caspase 8 Enzyme 3.7E-06 0.404 0.923 6
FGF3 P11487 fibroblast growth factor 3 Signaling 9.3E-05 0.505 0.808 4
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 33
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 22
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 29
FGF4 P08620 fibroblast growth factor 4 Signaling 0.14 0.588 0.577 4
FOXA1 P55317 forkhead box A1 Transcription factor 0.22 0.522 0.731 5
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 27
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 39
INPP4B O15327 inositol polyphosphate-4-phosphatase type II B 0.55 0.573 0.577 4
CDKN1B P46527 cyclin dependent kinase inhibitor 1B 0.62 0.409 0.769 8
AKT2 P31751 AKT serine/threonine kinase 2 Kinase 0.64 0.474 0.769 15
MAP3K13 O43283 mitogen-activated protein kinase kinase kinase 13 Kinase 0.80 0.743 0.192 4
GATA3 P23771 GATA binding protein 3 0.90 0.415 0.846 4
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 20
PDPK1 O15530 3-phosphoinositide dependent protein kinase 1 Kinase 0.98 0.588 0.808 4
TBX3 O15119 T-box transcription factor 3 Transcription factor 0.99 0.525 0.769 4
BAP1 Q92560 BRCA1 associated protein 1 Enzyme 0.99 0.454 0.731 14
MAP2K4 P45985 mitogen-activated protein kinase kinase 4 Kinase 1.00 0.559 0.692 9