Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
EGFR P00533 epidermal growth factor receptor 0.50 0.325 0.862 37
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha kinase; transferase 1.00 0.341 0.897 251
KRAS P01116 KRAS proto-oncogene, GTPase enzyme modulator 9.0E-04 0.350 0.724 374
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase 1.00 0.352 0.793 350
IGF1 P05019 insulin like growth factor 1 0.29 0.355 0.828 63
STAT3 P40763 signal transducer and activator of transcription 3 nucleic acid binding; transcription factor 1.00 0.358 0.862 102
FGFR1 P11362 fibroblast growth factor receptor 1 1.00 0.388 0.759 329
VDR P11473 vitamin D receptor nucleic acid binding; receptor; transcription factor 6.3E-05 0.390 0.793 84
TERT O14746 telomerase reverse transcriptase nucleic acid binding 1.00 0.393 0.828 167
HRAS P01112 HRas proto-oncogene, GTPase enzyme modulator 8.7E-02 0.404 0.828 238
LMNA P02545 lamin A/C 1.00 0.406 0.724 509
NOTCH1 P46531 notch 1 1.00 0.415 0.759 53
RET P07949 ret proto-oncogene 1.00 0.418 0.724 174
LAMC2 Q13753 laminin subunit gamma 2 enzyme modulator; extracellular matrix protein; receptor 3.6E-12 0.419 0.931 47
SMAD4 Q13485 SMAD family member 4 transcription factor 1.00 0.430 0.759 168
GJA1 P17302 gap junction protein alpha 1 cell junction protein 0.14 0.431 0.793 251
GNAS O95467 P63092 P84996 Q5JWF2 GNAS complex locus enzyme modulator 0.71 0.443 0.793 184
CASP8 Q14790 caspase 8 enzyme modulator; hydrolase; protease 2.8E-06 0.443 0.793 26
ERCC2 P18074 ERCC excision repair 2, TFIIH core complex helicase subunit nucleic acid binding 1.7E-20 0.447 0.828 179
CREBBP Q92793 CREB binding protein nucleic acid binding; transcription factor; transferase 1.00 0.451 0.862 204
ACTB P60709 actin beta cytoskeletal protein 0.99 0.453 0.862 150
CFTR P13569 cystic fibrosis transmembrane conductance regulator transporter 1.1E-57 0.453 0.793 54
FLNA P21333 filamin A 1.00 0.456 0.793 373
INS P01308 insulin 0.32 0.458 0.828 64