Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 10 32
KIT P10721 KIT proto-oncogene, receptor tyrosine kinase Kinase 0.98 0.366 0.808 7 15
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885 7 45
FGFR3 P22607 fibroblast growth factor receptor 3 Kinase 1.6E-05 0.391 0.846 17 14
RET P07949 ret proto-oncogene Kinase 1.00 0.392 0.885 10 57
MAP2K7 O14733 mitogen-activated protein kinase kinase 7 Kinase 1.00 0.419 0.808 1 0
ROS1 P08922 ROS proto-oncogene 1, receptor tyrosine kinase Kinase 1.6E-72 0.439 0.885 3 1
PRKCA P17252 protein kinase C alpha Kinase 0.37 0.440 0.846 2 0
PRKCB P05771 protein kinase C beta Kinase 1.00 0.453 0.885 2 2
ERBB4 Q15303 erb-b2 receptor tyrosine kinase 4 Kinase 1.00 0.455 0.846 3 2
TTN Q8WZ42 titin Kinase 2.6E-96 0.470 0.885 16 32
AURKA O14965 aurora kinase A Kinase 0.87 0.475 0.731 2 0
RIPK1 Q13546 receptor interacting serine/threonine kinase 1 Kinase 7.9E-03 0.479 0.769 1 3
PIM1 P11309 Pim-1 proto-oncogene, serine/threonine kinase Kinase 0.85 0.482 0.769 1 0
ROR2 Q01974 receptor tyrosine kinase like orphan receptor 2 Kinase 1.2E-04 0.498 0.731 2 3
TYK2 P29597 tyrosine kinase 2 Kinase 4.5E-08 0.505 0.769 1 0
TBK1 Q9UHD2 TANK binding kinase 1 Kinase 7.5E-02 0.513 0.846 3 9
GRK2 P25098 G protein-coupled receptor kinase 2 Kinase 1.00 0.532 0.654 1 0
PRKDC P78527 protein kinase, DNA-activated, catalytic subunit Kinase 1.00 0.540 0.808 5 5
ROR1 Q01973 receptor tyrosine kinase like orphan receptor 1 Kinase 1.00 0.552 0.731 6 2
MAP2K4 P45985 mitogen-activated protein kinase kinase 4 Kinase 1.00 0.559 0.692 4 1
MAPK9 P45984 mitogen-activated protein kinase 9 Kinase 7.0E-02 0.561 0.731 2 0
PTK7 Q13308 protein tyrosine kinase 7 (inactive) Kinase 1.00 0.568 0.615 1 0
PAK3 O75914 p21 (RAC1) activated kinase 3 Kinase 0.99 0.569 0.731 2 2