Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
IL6 P05231 interleukin 6 0.32 0.248 0.962 270 4
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 192 93
INS P01308 insulin 0.30 0.445 0.923 157 34
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 138 5
HMOX1 P09601 heme oxygenase 1 9.7E-03 0.381 0.923 137 3
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 130 54
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 119 12
LEP P41159 leptin 0.46 0.349 0.846 114 3
PON1 P27169 paraoxonase 1 9.8E-11 0.409 0.885 112 15
GSTP1 P09211 glutathione S-transferase pi 1 1.4E-02 0.383 0.923 103 4
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 95 596
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 95 5
IL1RN P18510 interleukin 1 receptor antagonist 3.1E-02 0.373 0.923 92 30
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 80 3
IL2 P60568 interleukin 2 0.48 0.336 0.885 75 3
CDH1 P12830 cadherin 1 0.15 0.401 0.808 73 158
CLU P10909 clusterin 7.8E-05 0.426 0.885 66 7
NPPA P01160 natriuretic peptide A 5.5E-04 0.505 0.769 64 6
EPHX1 P07099 epoxide hydrolase 1 3.2E-09 0.500 0.846 63 0
PARP1 P09874 poly(ADP-ribose) polymerase 1 3.3E-04 0.389 0.923 62 3
CYP2E1 P05181 cytochrome P450 family 2 subfamily E member 1 8.1E-09 0.459 0.885 61 19
GSTM1 P09488 glutathione S-transferase mu 1 2.1E-03 0.380 0.923 61 1
ICAM1 P05362 intercellular adhesion molecule 1 3.5E-02 0.364 0.962 57 9
PAX6 P26367 paired box 6 1.00 0.450 0.769 55 109