Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 90
IL6 P05231 interleukin 6 0.32 0.248 0.962 54
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 92
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 40
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 60
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 86
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 45
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 64
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923 18
IL4 P05112 interleukin 4 4.7E-03 0.332 0.962 28
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 34
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 44
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 35
CASP3 P42574 caspase 3 Enzyme 0.10 0.351 0.923 62
NFE2L2 Q16236 nuclear factor, erythroid 2 like 2 Enzyme 3.6E-03 0.357 0.885 23
SERPINE1 P05121 serpin family E member 1 Enzyme modulator 4.4E-02 0.359 0.885 48
NOS2 P35228 nitric oxide synthase 2 4.0E-15 0.364 0.923 59
AGT P01019 angiotensinogen Enzyme modulator 5.0E-08 0.367 0.923 32
HMGB1 P09429 high mobility group box 1 Nucleic acid binding 0.82 0.368 0.923 23
CSF3 P09919 colony stimulating factor 3 0.38 0.377 0.885 4
SIRT1 Q96EB6 sirtuin 1 Epigenetic regulator 8.7E-02 0.378 0.885 20
SOD1 P00441 superoxide dismutase 1 Enzyme 0.18 0.379 0.962 17
MAPK3 P27361 mitogen-activated protein kinase 3 Kinase 3.7E-02 0.379 0.885 11
HMOX1 P09601 heme oxygenase 1 9.7E-03 0.381 0.923 69