Source: RGD

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
DNMT3A Q9Y6K1 DNA methyltransferase 3 alpha 7.4E-39 0.445 0.846 11
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 64
NOD2 Q9HC29 nucleotide binding oligomerization domain containing 2 Enzyme 2.0E-30 0.423 0.923 6
ABCC8 Q09428 ATP binding cassette subfamily C member 8 Transporter 8.0E-24 0.474 0.846 12
ERCC6 P0DP91 Q03468 ERCC excision repair 6, chromatin remodeling factor 5.2E-22 0.507 0.808 2
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 86
AGER Q15109 advanced glycosylation end-product specific receptor Receptor 6.4E-16 0.420 0.885 43
NOS2 P35228 nitric oxide synthase 2 4.0E-15 0.364 0.923 59
NAE1 Q13564 NEDD8 activating enzyme E1 subunit 1 Enzyme 1.8E-13 0.736 0.462 1
OGG1 O15527 8-oxoguanine DNA glycosylase 3.9E-12 0.453 0.808 9
GHRL Q9UBU3 ghrelin and obestatin prepropeptide 1.4E-11 0.517 0.769 9
NQO1 P15559 NAD(P)H quinone dehydrogenase 1 1.2E-09 0.434 0.885 40
CYP2E1 P05181 cytochrome P450 family 2 subfamily E member 1 8.1E-09 0.459 0.885 24
AGT P01019 angiotensinogen Enzyme modulator 5.0E-08 0.367 0.923 32
SERPINF1 P36955 serpin family F member 1 Enzyme modulator 7.8E-08 0.460 0.846 18
EPCAM P16422 epithelial cell adhesion molecule 1.3E-07 0.451 0.885 2
SMO Q99835 smoothened, frizzled class receptor G-protein coupled receptor 4.3E-07 0.489 0.731 5
TH P07101 tyrosine hydroxylase 1.7E-06 0.462 0.885 18
BCAN Q96GW7 brevican Extracellular structure 1.8E-06 0.700 0.269 4
CASP9 P55211 caspase 9 Enzyme 7.4E-06 0.458 0.808 37
APAF1 O14727 apoptotic peptidase activating factor 1 9.6E-06 0.525 0.769 8
HP P00738 haptoglobin Enzyme 1.7E-05 0.412 0.885 30
BNIP3 Q12983 BCL2 interacting protein 3 2.0E-05 0.520 0.731 14
PLAT P00750 plasminogen activator, tissue type Enzyme 5.7E-05 0.445 0.885 15