Source: HPO

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 131
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 95
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 209
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 128
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 255
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 187
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 254
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 337
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 119
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923 125
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923 62
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 27
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 73
EGF P01133 epidermal growth factor 8.5E-17 0.357 0.923 19
NFE2L2 Q16236 nuclear factor, erythroid 2 like 2 Enzyme 3.6E-03 0.357 0.885 12
NLRP3 Q96P20 NLR family pyrin domain containing 3 8.1E-04 0.361 0.962 93
FGFR1 P11362 fibroblast growth factor receptor 1 Kinase 1.00 0.362 0.885 303
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923 147
TERT O14746 telomerase reverse transcriptase Enzyme 0.99 0.374 0.846 142
EZH2 Q15910 enhancer of zeste 2 polycomb repressive complex 2 subunit Epigenetic regulator 1.00 0.376 0.885 83
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 176
BRCA2 P51587 BRCA2 DNA repair associated Nucleic acid binding 2.4E-25 0.379 0.846 140
FGFR2 P21802 fibroblast growth factor receptor 2 Kinase 1.00 0.380 0.808 301
EDN1 P05305 endothelin 1 Signaling 0.46 0.380 0.846 37