Source: RGD

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
XDH P47989 xanthine dehydrogenase Enzyme 2.6E-22 0.529 0.846 38
CASP9 P55211 caspase 9 Enzyme 7.4E-06 0.458 0.808 37
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 34
C3 P01024 complement C3 Enzyme modulator 0.90 0.445 0.885 33
IGF1R P08069 insulin like growth factor 1 receptor Kinase 0.97 0.399 0.885 33
AGT P01019 angiotensinogen Enzyme modulator 5.0E-08 0.367 0.923 32
CASP8 Q14790 caspase 8 Enzyme 3.7E-06 0.404 0.923 31
ANXA1 P04083 annexin A1 1.2E-07 0.442 0.885 30
BAD Q92934 BCL2 associated agonist of cell death 4.6E-03 0.553 0.769 30
HP P00738 haptoglobin Enzyme 1.7E-05 0.412 0.885 30
MFN2 O95140 mitofusin 2 Enzyme 0.99 0.471 0.846 29
LEP P41159 leptin 0.46 0.349 0.846 28
GJA1 P17302 gap junction protein alpha 1 Cell-cell junction 0.16 0.393 0.885 27
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 27
AGTR1 P30556 angiotensin II receptor type 1 G-protein coupled receptor 5.3E-04 0.423 0.846 26
CCR5 P51681 C-C motif chemokine receptor 5 (gene/pseudogene) G-protein coupled receptor 4.3E-10 0.398 0.885 26
GSK3B P49841 glycogen synthase kinase 3 beta Kinase 0.96 0.430 0.846 26
MIF P14174 macrophage migration inhibitory factor 1.2E-02 0.412 0.885 26
NR3C1 P04150 nuclear receptor subfamily 3 group C member 1 Nuclear receptor 0.97 0.393 0.885 26
RELA Q04206 RELA proto-oncogene, NF-kB subunit Transcription factor 1.00 0.406 0.885 26
ESR2 Q92731 estrogen receptor 2 Nuclear receptor 4.5E-08 0.400 0.923 25
NGF P01138 nerve growth factor Signaling 0.82 0.391 0.885 24
NFE2L2 Q16236 nuclear factor, erythroid 2 like 2 Enzyme 3.6E-03 0.357 0.885 23
NGFR P08138 nerve growth factor receptor Receptor 9.8E-02 0.477 0.846 23