Source: HPO

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 10
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 7
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923 62
HLA-DRB1 P01911 major histocompatibility complex, class II, DR beta 1 Immune response 1.1E-03 0.333 0.923 151
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 82
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 27
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 58
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 73
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923 55
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 18
ABCB1 P08183 ATP binding cassette subfamily B member 1 Transporter 1.3E-05 0.344 0.885 1
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 29
LEP P41159 leptin 0.46 0.349 0.846 25
AR P10275 androgen receptor Nuclear receptor 0.99 0.351 0.846 59
COX2 P00403 cytochrome c oxidase subunit II Enzyme 0.352 0.962 131
VDR P11473 vitamin D receptor Nuclear receptor 1.7E-05 0.352 0.885 70
SPP1 P10451 secreted phosphoprotein 1 2.1E-06 0.353 0.885 48
POMC P01189 proopiomelanocortin 1.2E-04 0.356 0.846 25
EGF P01133 epidermal growth factor 8.5E-17 0.357 0.923 19
NFE2L2 Q16236 nuclear factor, erythroid 2 like 2 Enzyme 3.6E-03 0.357 0.885 12
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 106
CAT P04040 catalase Enzyme 1.6E-10 0.359 0.962 2
SERPINE1 P05121 serpin family E member 1 Enzyme modulator 4.4E-02 0.359 0.885 1
NLRP3 Q96P20 NLR family pyrin domain containing 3 8.1E-04 0.361 0.962 93