Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
NFKB1 P19838 nuclear factor kappa B subunit 1 1.00 0.365 0.931 535 16
MTHFR P42898 methylenetetrahydrofolate reductase 1.2E-09 0.354 0.828 526 22
STAT3 P40763 signal transducer and activator of transcription 3 nucleic acid binding; transcription factor 1.00 0.358 0.862 521 18
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase 1.00 0.352 0.793 513 36
AKT1 P31749 AKT serine/threonine kinase 1 calcium-binding protein; kinase; transfer/carrier protein; transferase 0.98 0.355 0.862 513 11
ACE P12821 angiotensin I converting enzyme hydrolase; protease 1.6E-37 0.367 0.897 512 39
IL1A P01583 interleukin 1 alpha 1.5E-04 0.366 0.931 511 11
IL2 P60568 interleukin 2 0.49 0.373 0.931 507 3
ABCB1 P08183 ATP binding cassette subfamily B member 1 hydrolase; protease 1.3E-05 0.371 0.828 505 24
CCND1 P24385 cyclin D1 enzyme modulator 0.90 0.365 0.828 500 4
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha nucleic acid binding; transcription factor 0.97 0.367 0.793 496 6
PIK3CD O00329 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta kinase; transferase 1.00 0.386 0.862 478 3
PIK3CG P48736 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma kinase; transferase 1.5E-06 0.385 0.862 475 3
AR P10275 androgen receptor nucleic acid binding; receptor; transcription factor 0.98 0.380 0.793 474 31
PIK3CB P42338 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta kinase; transferase 1.00 0.389 0.862 462 4
KRAS P01116 KRAS proto-oncogene, GTPase enzyme modulator 9.0E-04 0.350 0.724 461 19
SERPINE1 P05121 serpin family E member 1 enzyme modulator 4.7E-02 0.384 0.793 445 13
CXCR4 P61073 C-X-C motif chemokine receptor 4 1.4E-02 0.391 0.897 436 7
EGF P01133 epidermal growth factor 1.0E-16 0.386 0.897 435 13
BDNF P23560 brain derived neurotrophic factor signaling molecule 0.70 0.382 0.828 434 33
MMP2 P08253 matrix metallopeptidase 2 hydrolase; protease 0.84 0.373 0.862 434 16
MYC P01106 MYC proto-oncogene, bHLH transcription factor nucleic acid binding; transcription factor 1.00 0.382 0.724 434 2
IL17A Q16552 interleukin 17A 4.4E-02 0.391 0.862 426 13
VDR P11473 vitamin D receptor nucleic acid binding; receptor; transcription factor 6.3E-05 0.390 0.793 424 34