Source: CURATED

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
IL6 P05231 interleukin 6 0.32 0.248 0.962 270 4
POMC P01189 proopiomelanocortin 1.2E-04 0.356 0.846 241 7
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 232 407
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 231 5
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 192 93
CAT P04040 catalase Enzyme 1.6E-10 0.359 0.962 171 2
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 138 9
DRD2 P14416 dopamine receptor D2 G-protein coupled receptor 0.75 0.436 0.846 133 7
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 124 58
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 119 20
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 115 30
CNR1 P21554 cannabinoid receptor 1 G-protein coupled receptor 0.51 0.446 0.808 115 1
LEP P41159 leptin 0.46 0.349 0.846 114 3
OXT P01178 oxytocin/neurophysin I prepropeptide Signaling 0.71 0.615 0.423 110 1
OPRM1 P35372 opioid receptor mu 1 G-protein coupled receptor 7.9E-11 0.457 0.808 109 4
NPY P01303 neuropeptide Y Signaling 0.14 0.447 0.846 109 0
CRH P06850 corticotropin releasing hormone Signaling 0.72 0.439 0.808 107 2
PDYN P01213 prodynorphin Signaling 1.7E-04 0.535 0.577 102 7
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 101 18
TRH P20396 thyrotropin releasing hormone 8.9E-04 0.519 0.846 100 1
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 98 8
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 95 5
HTR1A P08908 5-hydroxytryptamine receptor 1A G-protein coupled receptor 0.20 0.522 0.846 93 1
IL1RN P18510 interleukin 1 receptor antagonist 3.1E-02 0.373 0.923 92 30