Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 92
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 76
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 64
CASP3 P42574 caspase 3 Enzyme 0.10 0.351 0.923 62
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 60
NOS2 P35228 nitric oxide synthase 2 4.0E-15 0.364 0.923 59
IL6 P05231 interleukin 6 0.32 0.248 0.962 54
BAX Q07812 BCL2 associated X, apoptosis regulator Signaling 0.32 0.417 0.885 44
AGER Q15109 advanced glycosylation end-product specific receptor Receptor 6.4E-16 0.420 0.885 43
CASP9 P55211 caspase 9 Enzyme 7.4E-06 0.458 0.808 37
PPARGC1A Q9UBK2 PPARG coactivator 1 alpha Transcription factor 1.00 0.453 0.885 37
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 35
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 34
IGF1R P08069 insulin like growth factor 1 receptor Kinase 0.97 0.399 0.885 33
CASP8 Q14790 caspase 8 Enzyme 3.7E-06 0.404 0.923 31
GSR P00390 glutathione-disulfide reductase Enzyme 1.3E-06 0.494 0.846 31
MFN2 O95140 mitofusin 2 Enzyme 0.99 0.471 0.846 29
LEP P41159 leptin 0.46 0.349 0.846 28
CCR5 P51681 C-C motif chemokine receptor 5 (gene/pseudogene) G-protein coupled receptor 4.3E-10 0.398 0.885 26
GSK3B P49841 glycogen synthase kinase 3 beta Kinase 0.96 0.430 0.846 26
NGF P01138 nerve growth factor Signaling 0.82 0.391 0.885 24
CASP12 Q6UXS9 caspase 12 (gene/pseudogene) 1.3E-04 0.638 0.808 23
IGF2 P01344 insulin like growth factor 2 4.4E-02 0.390 0.885 23
NFE2L2 Q16236 nuclear factor, erythroid 2 like 2 Enzyme 3.6E-03 0.357 0.885 23