Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor signaling molecule 0.80 0.263 0.966 225
IL6 P05231 interleukin 6 0.34 0.287 0.966 177
VEGFA P15692 vascular endothelial growth factor A signaling molecule 2.7E-05 0.298 0.897 171
TP53 P04637 tumor protein p53 transcription factor 0.17 0.251 0.897 170
TGFB1 P01137 transforming growth factor beta 1 signaling molecule 0.17 0.336 0.931 156
MMP9 P14780 matrix metallopeptidase 9 hydrolase; protease 7.0E-18 0.339 0.862 149
IL10 P22301 interleukin 10 6.5E-03 0.320 0.931 134
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 oxidoreductase 1.00 0.338 0.897 118
IL1B P01584 interleukin 1 beta 0.13 0.312 0.931 111
CXCL8 P10145 C-X-C motif chemokine ligand 8 signaling molecule 0.342 0.862 100
IFNG P01579 interferon gamma 0.47 0.323 0.897 91
ICAM1 P05362 intercellular adhesion molecule 1 3.8E-02 0.386 0.897 89
APOE P02649 apolipoprotein E 1.7E-03 0.352 0.931 84
IGF1 P05019 insulin like growth factor 1 0.29 0.355 0.828 84
TLR4 O00206 toll like receptor 4 5.6E-09 0.359 0.931 84
BCL2 P10415 BCL2, apoptosis regulator signaling molecule 0.57 0.312 0.862 83
CCL2 P13500 C-C motif chemokine ligand 2 signaling molecule 0.62 0.353 0.897 82
LEP P41159 leptin 0.39 0.400 0.793 77
NOS3 P29474 nitric oxide synthase 3 8.9E-07 0.401 0.862 77
FAS P25445 Fas cell surface death receptor 0.84 0.393 0.862 76
NFKB1 P19838 nuclear factor kappa B subunit 1 1.00 0.365 0.931 72
ESR1 P03372 estrogen receptor 1 nucleic acid binding; receptor; transcription factor 1.00 0.355 0.897 71
NOS2 P35228 nitric oxide synthase 2 1.5E-14 0.385 0.931 67
TERT O14746 telomerase reverse transcriptase nucleic acid binding 1.00 0.393 0.828 66