Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor signaling molecule 0.80 0.263 0.966 225
IL6 P05231 interleukin 6 0.34 0.287 0.966 177
VEGFA P15692 vascular endothelial growth factor A signaling molecule 2.7E-05 0.298 0.897 171
TGFB1 P01137 transforming growth factor beta 1 signaling molecule 0.17 0.336 0.931 156
MMP9 P14780 matrix metallopeptidase 9 hydrolase; protease 7.0E-18 0.339 0.862 149
IL10 P22301 interleukin 10 6.5E-03 0.320 0.931 134
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 oxidoreductase 1.00 0.338 0.897 118
IL1B P01584 interleukin 1 beta 0.13 0.312 0.931 111
MTHFR P42898 methylenetetrahydrofolate reductase 1.2E-09 0.354 0.828 111
MMP2 P08253 matrix metallopeptidase 2 hydrolase; protease 0.84 0.373 0.862 95
ICAM1 P05362 intercellular adhesion molecule 1 3.8E-02 0.386 0.897 89
CRP P02741 C-reactive protein 3.7E-03 0.399 0.862 85
APOE P02649 apolipoprotein E 1.7E-03 0.352 0.931 84
IGF1 P05019 insulin like growth factor 1 0.29 0.355 0.828 84
IL18 Q14116 interleukin 18 2.9E-02 0.404 0.862 84
TLR4 O00206 toll like receptor 4 5.6E-09 0.359 0.931 84
CCL2 P13500 C-C motif chemokine ligand 2 signaling molecule 0.62 0.353 0.897 82
NOS3 P29474 nitric oxide synthase 3 8.9E-07 0.401 0.862 77
PPARG P37231 peroxisome proliferator activated receptor gamma nucleic acid binding; receptor; transcription factor 0.14 0.388 0.828 77
NFKB1 P19838 nuclear factor kappa B subunit 1 1.00 0.365 0.931 72
ESR1 P03372 estrogen receptor 1 nucleic acid binding; receptor; transcription factor 1.00 0.355 0.897 71
SERPINE1 P05121 serpin family E member 1 enzyme modulator 4.7E-02 0.384 0.793 71
ADIPOQ Q15848 adiponectin, C1Q and collagen domain containing 5.0E-09 0.485 0.724 67
FASLG P48023 Fas ligand signaling molecule 0.18 0.462 0.862 66