Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
IL6 P05231 interleukin 6 0.32 0.248 0.962 262
POMC P01189 proopiomelanocortin 1.2E-04 0.356 0.846 238
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 234
NOS2 P35228 nitric oxide synthase 2 4.0E-15 0.364 0.923 182
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 178
CAT P04040 catalase Enzyme 1.6E-10 0.359 0.962 169
IFNG P01579 interferon gamma 0.47 0.288 0.962 157
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 145
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 133
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 111
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 109
PON1 P27169 paraoxonase 1 9.8E-11 0.409 0.885 107
LEP P41159 leptin 0.46 0.349 0.846 104
OXT P01178 oxytocin/neurophysin I prepropeptide Signaling 0.71 0.615 0.423 103
GSTP1 P09211 glutathione S-transferase pi 1 1.4E-02 0.383 0.923 98
PRL P01236 prolactin Signaling 2.9E-07 0.406 0.885 95
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 92
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 90
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 89
IL1RN P18510 interleukin 1 receptor antagonist 3.1E-02 0.373 0.923 85
MECP2 P51608 methyl-CpG binding protein 2 Epigenetic regulator 0.89 0.414 0.846 85
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 77
CP P00450 ceruloplasmin Enzyme 4.2E-10 0.466 0.846 74
IL2 P60568 interleukin 2 0.48 0.336 0.885 73