Source: CGI

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 45
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 33
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 33
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 28
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 27
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 22
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 20
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808 17
STK11 Q15831 serine/threonine kinase 11 Kinase 0.99 0.435 0.808 17
AKT2 P31751 AKT serine/threonine kinase 2 Kinase 0.64 0.474 0.769 15
FGFR2 P21802 fibroblast growth factor receptor 2 Kinase 1.00 0.380 0.808 15
BAP1 Q92560 BRCA1 associated protein 1 Enzyme 0.99 0.454 0.731 14
MET P08581 MET proto-oncogene, receptor tyrosine kinase Kinase 0.97 0.380 0.846 13
ALK Q9UM73 ALK receptor tyrosine kinase Kinase 3.2E-06 0.396 0.846 11
MAP2K1 Q02750 mitogen-activated protein kinase kinase 1 Kinase 0.90 0.439 0.846 10
RET P07949 ret proto-oncogene Kinase 1.00 0.392 0.885 9
SMARCA4 P51532 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Epigenetic regulator 1.00 0.450 0.885 6
KDR P35968 kinase insert domain receptor Kinase 1.00 0.378 0.885 3
MAP2K2 P36507 mitogen-activated protein kinase kinase 2 Kinase 0.97 0.534 0.731 3
NFE2L2 Q16236 nuclear factor, erythroid 2 like 2 Enzyme 3.6E-03 0.357 0.885 2
SOX2 P48431 SRY-box transcription factor 2 Transcription factor 0.71 0.405 0.808 2
NKX2-1 P43699 NK2 homeobox 1 Transcription factor 0.36 0.457 0.808 1