Source: ANIMAL_MODELS

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 138
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 101
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 62
CASP3 P42574 caspase 3 Enzyme 0.10 0.351 0.923 62
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 59
FAS P25445 Fas cell surface death receptor 0.81 0.372 0.923 49
BAX Q07812 BCL2 associated X, apoptosis regulator Signaling 0.32 0.417 0.885 44
PPARGC1A Q9UBK2 PPARG coactivator 1 alpha Transcription factor 1.00 0.453 0.885 42
CASP9 P55211 caspase 9 Enzyme 7.4E-06 0.458 0.808 37
CASP8 Q14790 caspase 8 Enzyme 3.7E-06 0.404 0.923 35
AGTR1 P30556 angiotensin II receptor type 1 G-protein coupled receptor 5.3E-04 0.423 0.846 34
AGT P01019 angiotensinogen Enzyme modulator 5.0E-08 0.367 0.923 32
SOD2 P04179 superoxide dismutase 2 Enzyme 0.15 0.379 0.923 31
CXCL1 P09341 C-X-C motif chemokine ligand 1 Signaling 0.12 0.449 0.923 30
AGTR2 P50052 angiotensin II receptor type 2 G-protein coupled receptor 8.2E-03 0.496 0.808 22
PTPN11 Q06124 protein tyrosine phosphatase non-receptor type 11 1.00 0.385 0.923 22
ADRB2 P07550 adrenoceptor beta 2 G-protein coupled receptor 0.53 0.442 0.923 20
SCN5A Q14524 sodium voltage-gated channel alpha subunit 5 Ion channel 0.91 0.513 0.654 20
BCL2L1 Q07817 BCL2 like 1 Signaling 0.94 0.493 0.885 17
ADRB1 P08588 adrenoceptor beta 1 G-protein coupled receptor 2.9E-06 0.555 0.769 16
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 16
PTGER4 P35408 prostaglandin E receptor 4 G-protein coupled receptor 0.98 0.558 0.731 14
DAG1 Q14118 dystroglycan 1 Receptor 0.98 0.498 0.808 13
RXRA P19793 retinoid X receptor alpha Nuclear receptor 1.00 0.543 0.769 13