Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 226
IL6 P05231 interleukin 6 0.32 0.248 0.962 177
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 171
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 169
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 156
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 149
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 118
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 112
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 110
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 100
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 95
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 95
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 94
IFNG P01579 interferon gamma 0.47 0.288 0.962 91
ICAM1 P05362 intercellular adhesion molecule 1 3.5E-02 0.364 0.962 89
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 86
CRP P02741 C-reactive protein 3.7E-03 0.299 0.962 85
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 84
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 84
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 84
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 83
IL18 Q14116 interleukin 18 3.1E-02 0.365 0.923 83
LEP P41159 leptin 0.46 0.349 0.846 78
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 77