Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TP53 P04637 tumor protein p53 transcription factor 0.17 0.251 0.897 1531 122
TNF P01375 tumor necrosis factor signaling molecule 0.80 0.263 0.966 1382 18
IL6 P05231 interleukin 6 0.34 0.287 0.966 1091 15
VEGFA P15692 vascular endothelial growth factor A signaling molecule 2.7E-05 0.298 0.897 1000 32
BCL2 P10415 BCL2, apoptosis regulator signaling molecule 0.57 0.312 0.862 839 16
IL10 P22301 interleukin 10 6.5E-03 0.320 0.931 837 17
EGFR P00533 epidermal growth factor receptor 0.50 0.325 0.862 810 48
IL1B P01584 interleukin 1 beta 0.13 0.312 0.931 810 15
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.38 0.321 0.828 792 44
IFNG P01579 interferon gamma 0.47 0.323 0.897 760 6
CXCL8 P10145 C-X-C motif chemokine ligand 8 signaling molecule 0.342 0.862 670 7
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 oxidoreductase 1.00 0.338 0.897 624 24
TGFB1 P01137 transforming growth factor beta 1 signaling molecule 0.17 0.336 0.931 620 13
APOE P02649 apolipoprotein E 1.7E-03 0.352 0.931 609 24
MMP9 P14780 matrix metallopeptidase 9 hydrolase; protease 7.0E-18 0.339 0.862 608 14
HLA-DRB1 P01911 P01912 P04229 P13760 P13761 P20039 Q29974 Q30134 Q30167 Q5Y7A7 Q95IE3 Q9GIY3 Q9TQE0 major histocompatibility complex, class II, DR beta 1 defense/immunity protein 1.0E-03 0.347 0.897 604 5
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha kinase; transferase 1.00 0.341 0.897 597 16
PTEN P60484 phosphatase and tensin homolog hydrolase; phosphatase 0.82 0.334 0.828 575 22
ESR1 P03372 estrogen receptor 1 nucleic acid binding; receptor; transcription factor 1.00 0.355 0.897 564 62
TLR4 O00206 toll like receptor 4 5.6E-09 0.359 0.931 562 25
IGF1 P05019 insulin like growth factor 1 0.29 0.355 0.828 548 16
CCL2 P13500 C-C motif chemokine ligand 2 signaling molecule 0.62 0.353 0.897 548 5
IL4 P05112 interleukin 4 5.3E-03 0.364 0.931 547 10
NFKB1 P19838 nuclear factor kappa B subunit 1 1.00 0.365 0.931 535 16