Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 90
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 86
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 82
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 76
HMOX1 P09601 heme oxygenase 1 9.7E-03 0.381 0.923 69
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 69
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 60
NOS2 P35228 nitric oxide synthase 2 4.0E-15 0.364 0.923 59
ICAM1 P05362 intercellular adhesion molecule 1 3.5E-02 0.364 0.962 54
IL6 P05231 interleukin 6 0.32 0.248 0.962 54
EDN1 P05305 endothelin 1 Signaling 0.46 0.380 0.846 48
SERPINE1 P05121 serpin family E member 1 Enzyme modulator 4.4E-02 0.359 0.885 48
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 45
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 45
BAX Q07812 BCL2 associated X, apoptosis regulator Signaling 0.32 0.417 0.885 44
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 44
NOS1 P29475 nitric oxide synthase 1 1.00 0.408 0.885 44
AGER Q15109 advanced glycosylation end-product specific receptor Receptor 6.4E-16 0.420 0.885 43
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 40
BECN1 Q14457 beclin 1 Enzyme modulator 0.94 0.432 0.846 39
PPARGC1A Q9UBK2 PPARG coactivator 1 alpha Transcription factor 1.00 0.453 0.885 37
IGF1R P08069 insulin like growth factor 1 receptor Kinase 0.97 0.399 0.885 33
BAD Q92934 BCL2 associated agonist of cell death 4.6E-03 0.553 0.769 30
HP P00738 haptoglobin Enzyme 1.7E-05 0.412 0.885 30