Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
BRCA2 P51587 BRCA2, DNA repair associated nucleic acid binding 5.5E-24 0.426 0.793 7
FANCB Q8NB91 FA complementation group B 1.00 0.520 0.586 4
PALB2 Q86YC2 partner and localizer of BRCA2 7.3E-20 0.569 0.552 4
ERCC4 Q92889 ERCC excision repair 4, endonuclease catalytic subunit nucleic acid binding 3.8E-12 0.503 0.724 3
BRIP1 Q9BX63 BRCA1 interacting protein C-terminal helicase 1 nucleic acid binding 4.8E-17 0.586 0.552 2
RAD51 Q06609 RAD51 recombinase 3.3E-02 0.517 0.724 2
RAD51C O43502 RAD51 paralog C 1.1E-13 0.614 0.517 2
XRCC2 O43543 X-ray repair cross complementing 2 4.2E-07 0.609 0.586 2
FANCA O15360 FA complementation group A 4.3E-68 0.567 0.621 1
FANCC Q00597 FA complementation group C 2.6E-13 0.569 0.655 1
FANCD2 Q9BXW9 FA complementation group D2 2.1E-30 0.534 0.724 1
FANCE Q9HB96 FA complementation group E 8.8E-06 0.636 0.586 1
FANCF Q9NPI8 FA complementation group F 0.46 0.627 0.552 1
FANCG O15287 FA complementation group G 2.1E-13 0.648 0.483 1
FANCI Q9NVI1 FA complementation group I 2.8E-35 0.701 0.414 1
FANCL Q9NW38 FA complementation group L ligase 8.1E-23 0.642 0.586 1
FANCM Q8IYD8 FA complementation group M nucleic acid binding 6.3E-15 0.672 0.414 1
MAD2L2 Q9UI95 mitotic arrest deficient 2 like 2 8.3E-02 0.690 0.517 1
RFWD3 Q6PCD5 ring finger and WD repeat domain 3 ligase 4.2E-10 0.762 0.414 1
SLX4 Q8IY92 SLX4 structure-specific endonuclease subunit 2.3E-20 0.672 0.517 1
UBE2T Q9NPD8 ubiquitin conjugating enzyme E2 T 1.2E-05 0.681 0.448 1