Source: CGI

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 45
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 39
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 33
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 28
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 27
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885 20
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 18
ATR Q13535 ATR serine/threonine kinase Kinase 3.5E-09 0.456 0.923 16
STAG2 Q8N3U4 stromal antigen 2 Nucleic acid binding 1.00 0.568 0.731 12
ALK Q9UM73 ALK receptor tyrosine kinase Kinase 3.2E-06 0.396 0.846 11
PMS2 P54278 PMS1 homolog 2, mismatch repair system component Nucleic acid binding 4.5E-27 0.484 0.808 10
IDH1 O75874 isocitrate dehydrogenase (NADP(+)) 1 2.6E-12 0.424 0.808 9
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 8
KLF6 Q99612 Kruppel like factor 6 Nucleic acid binding 0.98 0.501 0.846 8
NF1 P21359 neurofibromin 1 Enzyme modulator 0.90 0.440 0.885 8
PIK3R1 P27986 phosphoinositide-3-kinase regulatory subunit 1 Kinase 1.00 0.477 0.885 8
MDM2 Q00987 MDM2 proto-oncogene Nucleic acid binding 1.00 0.362 0.846 4
NBN O60934 nibrin Nucleic acid binding 2.2E-16 0.467 0.808 4
CDKN2C P42773 cyclin dependent kinase inhibitor 2C 0.40 0.527 0.654 3
CDKN2B P42772 cyclin dependent kinase inhibitor 2B 7.3E-03 0.417 0.769 2
CIC Q96RK0 capicua transcriptional repressor 1.00 0.523 0.692 2
ACVR1 Q04771 activin A receptor type 1 Kinase 0.33 0.535 0.731 1
FUBP1 Q96AE4 far upstream element binding protein 1 Enzyme 1.00 0.610 0.615 1