Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 226
IL6 P05231 interleukin 6 0.32 0.248 0.962 177
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 171
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 156
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 149
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 134
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 112
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 110
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 95
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 94
HLA-DRB1 P01911 major histocompatibility complex, class II, DR beta 1 Immune response 1.1E-03 0.333 0.923 88
CRP P02741 C-reactive protein 3.7E-03 0.299 0.962 85
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 84
LEP P41159 leptin 0.46 0.349 0.846 78
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 77
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 77
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 71
SERPINE1 P05121 serpin family E member 1 Enzyme modulator 4.4E-02 0.359 0.885 71
ADIPOQ Q15848 adiponectin, C1Q and collagen domain containing 4.6E-09 0.376 0.885 67
NOS2 P35228 nitric oxide synthase 2 4.0E-15 0.364 0.923 67
TIMP1 P01033 TIMP metallopeptidase inhibitor 1 Enzyme modulator 0.50 0.380 0.885 64
EDN1 P05305 endothelin 1 Signaling 0.46 0.380 0.846 63
GSTM1 P09488 glutathione S-transferase mu 1 2.1E-03 0.380 0.923 62
HGF P14210 hepatocyte growth factor Enzyme 1.00 0.374 0.885 61