Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
MMP9 P14780 matrix metallopeptidase 9 hydrolase; protease 7.0E-18 0.339 0.862 60
IL1B P01584 interleukin 1 beta 0.13 0.312 0.931 57
CCL2 P13500 C-C motif chemokine ligand 2 signaling molecule 0.62 0.353 0.897 53
TNF P01375 tumor necrosis factor signaling molecule 0.80 0.263 0.966 48
BCL2 P10415 BCL2, apoptosis regulator signaling molecule 0.57 0.312 0.862 43
ACE P12821 angiotensin I converting enzyme hydrolase; protease 1.6E-37 0.367 0.897 42
NOS3 P29474 nitric oxide synthase 3 8.9E-07 0.401 0.862 41
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 oxidoreductase 1.00 0.338 0.897 41
MMP2 P08253 matrix metallopeptidase 2 hydrolase; protease 0.84 0.373 0.862 37
EDN1 P05305 endothelin 1 signaling molecule 0.46 0.417 0.828 36
HMOX1 P09601 heme oxygenase 1 oxidoreductase 7.9E-03 0.403 0.862 36
IL10 P22301 interleukin 10 6.5E-03 0.320 0.931 36
NOS2 P35228 nitric oxide synthase 2 1.5E-14 0.385 0.931 36
AGER Q15109 advanced glycosylation end-product specific receptor cell adhesion molecule; receptor 3.4E-16 0.472 0.724 33
SERPINE1 P05121 serpin family E member 1 enzyme modulator 4.7E-02 0.384 0.793 31
CAT P04040 catalase oxidoreductase 1.9E-10 0.397 0.828 30
BAX Q07812 BCL2 associated X, apoptosis regulator signaling molecule 0.30 0.450 0.862 29
BECN1 Q14457 beclin 1 enzyme modulator 0.91 0.497 0.759 27
MTOR P42345 mechanistic target of rapamycin kinase kinase; nucleic acid binding; transferase 1.00 0.399 0.793 27
AGT P01019 angiotensinogen enzyme modulator 3.9E-08 0.406 0.862 25
NOS1 P29475 nitric oxide synthase 1 1.00 0.445 0.793 25
IGF1 P05019 insulin like growth factor 1 0.29 0.355 0.828 23
NQO1 P15559 NAD(P)H quinone dehydrogenase 1 1.0E-09 0.467 0.724 23
TGFB1 P01137 transforming growth factor beta 1 signaling molecule 0.17 0.336 0.931 23