Source: RGD

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 86
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 82
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 76
HMOX1 P09601 heme oxygenase 1 9.7E-03 0.381 0.923 69
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 69
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 60
NOS2 P35228 nitric oxide synthase 2 4.0E-15 0.364 0.923 59
IL6 P05231 interleukin 6 0.32 0.248 0.962 54
EDN1 P05305 endothelin 1 Signaling 0.46 0.380 0.846 48
SERPINE1 P05121 serpin family E member 1 Enzyme modulator 4.4E-02 0.359 0.885 48
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 45
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 44
AGT P01019 angiotensinogen Enzyme modulator 5.0E-08 0.367 0.923 32
CX3CL1 P78423 C-X3-C motif chemokine ligand 1 Signaling 0.61 0.478 0.808 27
GJA1 P17302 gap junction protein alpha 1 Cell-cell junction 0.16 0.393 0.885 27
CCN2 P29279 cellular communication network factor 2 Signaling 5.0E-04 0.399 0.846 26
CX3CR1 P49238 C-X3-C motif chemokine receptor 1 G-protein coupled receptor 6.1E-02 0.457 0.885 26
RELA Q04206 RELA proto-oncogene, NF-kB subunit Transcription factor 1.00 0.406 0.885 26
ANGPT2 O15123 angiopoietin 2 Signaling 0.83 0.410 0.846 25
ESR2 Q92731 estrogen receptor 2 Nuclear receptor 4.5E-08 0.400 0.923 25
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 25
CD40LG P29965 CD40 ligand Signaling 0.72 0.414 0.846 24
EGR1 P18146 early growth response 1 Nucleic acid binding 0.35 0.433 0.923 23
HMGB1 P09429 high mobility group box 1 Nucleic acid binding 0.82 0.368 0.923 23