Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
ABCB1 P08183 ATP binding cassette subfamily B member 1 hydrolase; protease 1.3E-05 0.371 0.828 65
CCL2 P13500 C-C motif chemokine ligand 2 signaling molecule 0.62 0.353 0.897 62
IL1B P01584 interleukin 1 beta 0.13 0.312 0.931 57
BCL2 P10415 BCL2, apoptosis regulator signaling molecule 0.57 0.312 0.862 44
NOS3 P29474 nitric oxide synthase 3 8.9E-07 0.401 0.862 44
ACE P12821 angiotensin I converting enzyme hydrolase; protease 1.6E-37 0.367 0.897 42
EDN1 P05305 endothelin 1 signaling molecule 0.46 0.417 0.828 36
ICAM1 P05362 intercellular adhesion molecule 1 3.8E-02 0.386 0.897 31
SERPINE1 P05121 serpin family E member 1 enzyme modulator 4.7E-02 0.384 0.793 31
CAT P04040 catalase oxidoreductase 1.9E-10 0.397 0.828 30
AGTR1 P30556 angiotensin II receptor type 1 receptor 5.7E-04 0.454 0.759 28
BECN1 Q14457 beclin 1 enzyme modulator 0.91 0.497 0.759 27
MTOR P42345 mechanistic target of rapamycin kinase kinase; nucleic acid binding; transferase 1.00 0.399 0.793 27
NOS1 P29475 nitric oxide synthase 1 1.00 0.445 0.793 27
TGFB1 P01137 transforming growth factor beta 1 signaling molecule 0.17 0.336 0.931 25
CCL5 P13501 C-C motif chemokine ligand 5 signaling molecule 1.7E-03 0.429 0.793 24
NQO1 P15559 NAD(P)H quinone dehydrogenase 1 1.0E-09 0.467 0.724 23
NR3C1 P04150 nuclear receptor subfamily 3 group C member 1 nucleic acid binding; receptor; transcription factor 0.98 0.427 0.793 21
PLAU P00749 plasminogen activator, urokinase hydrolase; protease 2.1E-06 0.434 0.690 18
XDH P47989 xanthine dehydrogenase oxidoreductase 5.0E-22 0.567 0.655 17
CCR5 P51681 C-C motif chemokine receptor 5 (gene/pseudogene) 5.3E-10 0.431 0.897 16
HP P00738 haptoglobin hydrolase; protease 7.4E-05 0.461 0.793 15
KL Q9UEF7 klotho hydrolase 2.2E-04 0.495 0.621 15
ADIPOQ Q15848 adiponectin, C1Q and collagen domain containing 5.0E-09 0.485 0.724 14