Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
PTCH1 Q13635 patched 1 1.00 0.398 0.885 116 144
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 107 343
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 84 390
BRCA2 P51587 BRCA2 DNA repair associated Nucleic acid binding 2.4E-25 0.379 0.846 68 2953
PALB2 Q86YC2 partner and localizer of BRCA2 3.0E-19 0.485 0.769 48 393
CHEK2 O96017 checkpoint kinase 2 Kinase 1.2E-24 0.460 0.808 48 209
NF1 P21359 neurofibromin 1 Enzyme modulator 0.90 0.440 0.885 47 887
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885 44 888
SMARCB1 Q12824 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Nucleic acid binding 1.00 0.434 0.846 43 27
RET P07949 ret proto-oncogene Kinase 1.00 0.392 0.885 36 77
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 33 582
PMS2 P54278 PMS1 homolog 2, mismatch repair system component Nucleic acid binding 4.5E-27 0.484 0.808 33 229
C11orf65 Q8NCR3 chromosome 11 open reading frame 65 2.0E-14 0.670 0.462 32 342
MITF O75030 melanocyte inducing transcription factor 0.98 0.499 0.808 25 24
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923 22 2439
STK11 Q15831 serine/threonine kinase 11 Kinase 0.99 0.435 0.808 22 129
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 22 83
MRE11 P49959 MRE11 homolog, double strand break repair nuclease 1.3E-12 0.527 0.808 21 61
MSH2 P43246 mutS homolog 2 Nucleic acid binding 0.90 0.406 0.808 20 682
MSH6 P52701 mutS homolog 6 Nucleic acid binding 3.7E-05 0.462 0.731 18 577
FBXO11 Q86XK2 F-box protein 11 Enzyme 1.00 0.604 0.692 18 561
SMAD4 Q13485 SMAD family member 4 Transcription factor 1.00 0.401 0.808 16 133
MUTYH Q9UIF7 mutY DNA glycosylase Enzyme 1.3E-18 0.521 0.769 16 130
MLH1 P40692 mutL homolog 1 Nucleic acid binding 3.4E-05 0.399 0.808 15 653