Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 382
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 342
FGFR1 P11362 fibroblast growth factor receptor 1 Kinase 1.00 0.362 0.885 330
FBN1 P35555 fibrillin 1 Calcium-binding protein 1.00 0.417 0.846 327
COL2A1 P02458 collagen type II alpha 1 chain 1.00 0.444 0.846 325
PTPN11 Q06124 protein tyrosine phosphatase non-receptor type 11 1.00 0.385 0.923 286
CHD7 Q9P2D1 chromodomain helicase DNA binding protein 7 1.00 0.441 0.846 281
POLG P54098 DNA polymerase gamma, catalytic subunit Enzyme 2.1E-09 0.457 0.846 279
GNAS O95467 P63092 P84996 Q5JWF2 GNAS complex locus Enzyme modulator 0.68 0.420 0.885 232
OFD1 O75665 OFD1 centriole and centriolar satellite protein 0.96 0.510 0.808 225
GJA1 P17302 gap junction protein alpha 1 Cell-cell junction 0.16 0.393 0.885 224
ATXN2 Q99700 ataxin 2 Nucleic acid binding 0.85 0.482 0.808 221
SDHD O14521 succinate dehydrogenase complex subunit D Transporter 0.34 0.472 0.885 221
ERCC2 P18074 ERCC excision repair 2, TFIIH core complex helicase subunit Enzyme 7.1E-20 0.420 0.846 220
BRCA2 P51587 BRCA2 DNA repair associated Nucleic acid binding 2.4E-25 0.379 0.846 218
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808 216
ND1 P03886 NADH dehydrogenase, subunit 1 (complex I) Enzyme 0.522 0.769 214
TRNL1 tRNA 0.534 0.731 213
PEX6 Q13608 peroxisomal biogenesis factor 6 6.3E-06 0.547 0.731 212
PEX1 O43933 peroxisomal biogenesis factor 1 1.1E-14 0.538 0.769 209
KMT2A Q03164 lysine methyltransferase 2A 1.00 0.410 0.885 205
ARID1B Q8NFD5 AT-rich interaction domain 1B 1.00 0.503 0.846 200
POLR3A O14802 RNA polymerase III subunit A Enzyme 1.3E-23 0.538 0.769 198
ND6 P03923 NADH dehydrogenase, subunit 6 (complex I) 0.544 0.808 196