Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
KRAS P01116 KRAS proto-oncogene, GTPase enzyme modulator 9.0E-04 0.350 0.724 374
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase 1.00 0.352 0.793 350
FGFR1 P11362 fibroblast growth factor receptor 1 1.00 0.388 0.759 329
PEX1 O43933 peroxisomal biogenesis factor 1 3.3E-14 0.554 0.655 231
ERCC6 P0DP91 Q03468 ERCC excision repair 6, chromatin remodeling factor 8.1E-22 0.507 0.690 211
PEX5 P50542 peroxisomal biogenesis factor 5 membrane traffic protein; receptor 1.1E-04 0.555 0.690 206
POLG P54098 DNA polymerase gamma, catalytic subunit nucleic acid binding; transferase 1.3E-09 0.477 0.724 205
PEX2 P28328 peroxisomal biogenesis factor 2 2.8E-04 0.575 0.621 185
GNAS O95467 P63092 P84996 Q5JWF2 GNAS complex locus enzyme modulator 0.71 0.443 0.793 184
RNU4ATAC RNA, U4atac small nuclear (U12-dependent splicing) 0.577 0.655 184
ERCC2 P18074 ERCC excision repair 2, TFIIH core complex helicase subunit nucleic acid binding 1.7E-20 0.447 0.828 179
OFD1 O75665 OFD1, centriole and centriolar satellite protein 0.97 0.547 0.724 179
PEX6 Q13608 peroxisomal biogenesis factor 6 3.7E-05 0.562 0.655 176
CHD7 Q9P2D1 chromodomain helicase DNA binding protein 7 1.00 0.504 0.724 175
SDHD O14521 succinate dehydrogenase complex subunit D transfer/carrier protein 0.21 0.499 0.793 174
NSD1 Q96L73 nuclear receptor binding SET domain protein 1 1.00 0.546 0.655 173
DHCR7 Q9UBM7 7-dehydrocholesterol reductase oxidoreductase; receptor 6.7E-12 0.527 0.759 168
MAP2K1 Q02750 mitogen-activated protein kinase kinase 1 0.91 0.459 0.759 168
PEX19 P40855 peroxisomal biogenesis factor 19 storage protein 3.2E-04 0.577 0.655 166
NIPBL Q6KC79 NIPBL, cohesin loading factor nucleic acid binding 1.00 0.557 0.690 162
ARID1B Q8NFD5 AT-rich interaction domain 1B 1.00 0.561 0.655 161
POMGNT1 Q8WZA1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 8.5E-20 0.557 0.483 161
PEX12 O00623 peroxisomal biogenesis factor 12 transfer/carrier protein 1.2E-15 0.586 0.621 154
PORCN Q9H237 porcupine O-acyltransferase transferase 1.00 0.557 0.586 150