Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
ATXN2 Q99700 ataxin 2 Nucleic acid binding 0.85 0.482 0.808 100 16
HLA-B P01889 major histocompatibility complex, class I, B 3.9E-05 0.379 0.885 94 101
GCKR Q14397 glucokinase regulator 8.5E-19 0.604 0.615 79 13
FADS2 O95864 fatty acid desaturase 2 1.00 0.575 0.692 74 50
SH2B3 Q9UQQ2 SH2B adaptor protein 3 1.0E-04 0.527 0.692 74 8
ABO P16442 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Enzyme 0.427 0.885 61 54
FADS1 O60427 fatty acid desaturase 1 0.37 0.582 0.769 53 30
HLA-A P04439 major histocompatibility complex, class I, A 1.3E-03 0.370 0.846 48 44
RAD51B O15315 RAD51 paralog B 2.1E-15 0.556 0.769 46 41
IRF1-AS1 Q8N8D9 IRF1 antisense RNA 1 4.2E-03 0.670 0.385 41 26
MIR4435-2HG MIR4435-2 host gene 0.604 0.692 38 56
RUNX1 Q01196 RUNX family transcription factor 1 Transcription factor 0.65 0.425 0.808 38 29
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 38 13
THADA Q6YHU6 THADA armadillo repeat containing Receptor 4.6E-41 0.686 0.500 37 33
CUX2 O14529 cut like homeobox 2 Transcription factor 1.00 0.644 0.500 36 10
JMJD1C Q15652 jumonji domain containing 1C 1.00 0.517 0.769 35 48
CASC15 cancer susceptibility 15 0.603 0.577 35 41
CPS1 P31327 carbamoyl-phosphate synthase 1 Enzyme 1.1E-09 0.590 0.615 32 5
MECOM Q03112 MDS1 and EVI1 complex locus 1.00 0.513 0.731 30 48
ZFPM2 Q8WW38 zinc finger protein, FOG family member 2 Transcription factor 1.00 0.565 0.731 30 27
HFE Q30201 homeostatic iron regulator 2.6E-08 0.436 0.846 30 9
ALDH2 P05091 aldehyde dehydrogenase 2 family member Enzyme 3.4E-10 0.457 0.885 30 6
MARK4 Q96L34 microtubule affinity regulating kinase 4 Kinase 1.00 0.641 0.615 28 44
TYK2 P29597 tyrosine kinase 2 Kinase 4.5E-08 0.505 0.769 27 8