Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
SOD2 P04179 superoxide dismutase 2 Enzyme 0.15 0.379 0.923 280
IL6 P05231 interleukin 6 0.32 0.248 0.962 262
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 234
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 185
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 178
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 170
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 160
INS P01308 insulin 0.30 0.445 0.923 153
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 145
HMOX1 P09601 heme oxygenase 1 9.7E-03 0.381 0.923 135
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 135
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 133
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 133
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 128
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 127
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 111
PLAU P00749 plasminogen activator, urokinase Enzyme 2.3E-06 0.425 0.923 109
PON1 P27169 paraoxonase 1 9.8E-11 0.409 0.885 107
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 105
LEP P41159 leptin 0.46 0.349 0.846 104
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 103
ACHE P22303 acetylcholinesterase (Cartwright blood group) Enzyme 1.00 0.445 0.885 99
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 99
GSTP1 P09211 glutathione S-transferase pi 1 1.4E-02 0.383 0.923 98