Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
SOD2 P04179 superoxide dismutase 2 oxidoreductase 0.16 0.396 0.897 290 0
IL6 P05231 interleukin 6 0.34 0.287 0.966 271 3
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 oxidoreductase 1.00 0.338 0.897 243 0
TP53 P04637 tumor protein p53 transcription factor 0.17 0.251 0.897 217 239
MTHFR P42898 methylenetetrahydrofolate reductase 1.2E-09 0.354 0.828 195 82
PTEN P60484 phosphatase and tensin homolog hydrolase; phosphatase 0.82 0.334 0.828 177 243
VEGFA P15692 vascular endothelial growth factor A signaling molecule 2.7E-05 0.298 0.897 176 2
TGFB1 P01137 transforming growth factor beta 1 signaling molecule 0.17 0.336 0.931 168 17
KRAS P01116 KRAS proto-oncogene, GTPase enzyme modulator 9.0E-04 0.350 0.724 160 34
INS P01308 insulin 0.32 0.458 0.828 150 31
HMOX1 P09601 heme oxygenase 1 oxidoreductase 7.9E-03 0.403 0.862 140 3
BCL2 P10415 BCL2, apoptosis regulator signaling molecule 0.57 0.312 0.862 137 8
MMP9 P14780 matrix metallopeptidase 9 hydrolase; protease 7.0E-18 0.339 0.862 135 9
NOS3 P29474 nitric oxide synthase 3 8.9E-07 0.401 0.862 127 3
EGFR P00533 epidermal growth factor receptor 0.50 0.325 0.862 124 51
CTNNB1 P35222 catenin beta 1 1.00 0.417 0.759 123 33
STAT3 P40763 signal transducer and activator of transcription 3 nucleic acid binding; transcription factor 1.00 0.358 0.862 122 32
HRAS P01112 HRas proto-oncogene, GTPase enzyme modulator 8.7E-02 0.404 0.828 119 20
AKT1 P31749 AKT serine/threonine kinase 1 calcium-binding protein; kinase; transfer/carrier protein; transferase 0.98 0.355 0.862 115 5
ESR1 P03372 estrogen receptor 1 nucleic acid binding; receptor; transcription factor 1.00 0.355 0.897 113 78
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase 1.00 0.352 0.793 110 79
IGF1 P05019 insulin like growth factor 1 0.29 0.355 0.828 110 8
PON1 P27169 paraoxonase 1 9.0E-11 0.443 0.828 110 5
BAP1 Q92560 BRCA1 associated protein 1 hydrolase; protease 0.99 0.488 0.586 109 23