Source: CTD_human

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 334
IL6 P05231 interleukin 6 0.32 0.248 0.962 262
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 224
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 185
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 178
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 148
DRD2 P14416 dopamine receptor D2 G-protein coupled receptor 0.75 0.436 0.846 118
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 111
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 109
CNR1 P21554 cannabinoid receptor 1 G-protein coupled receptor 0.51 0.446 0.808 109
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 89
NOS1 P29475 nitric oxide synthase 1 1.00 0.408 0.885 87
CP P00450 ceruloplasmin Enzyme 4.2E-10 0.466 0.846 74
MET P08581 MET proto-oncogene, receptor tyrosine kinase Kinase 0.97 0.380 0.846 73
TAC1 P20366 tachykinin precursor 1 0.75 0.424 0.923 72
AVP P01185 arginine vasopressin Signaling 7.4E-02 0.437 0.846 71
COMT P21964 catechol-O-methyltransferase Enzyme 1.1E-06 0.400 0.923 66
HLA-DRB1 P01911 major histocompatibility complex, class II, DR beta 1 Immune response 1.1E-03 0.333 0.923 58
SLC6A4 P31645 solute carrier family 6 member 4 Transporter 0.25 0.429 0.808 58
DRD3 P35462 dopamine receptor D3 G-protein coupled receptor 2.4E-03 0.529 0.692 57
F2 P00734 coagulation factor II, thrombin Enzyme 1.1E-03 0.415 0.885 57
FGFR1 P11362 fibroblast growth factor receptor 1 Kinase 1.00 0.362 0.885 57
HP P00738 haptoglobin Enzyme 1.7E-05 0.412 0.885 55
HTR2A P28223 5-hydroxytryptamine receptor 2A G-protein coupled receptor 0.51 0.473 0.846 53