Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase 1.00 0.352 0.793 45
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha kinase; transferase 1.00 0.341 0.897 33
ATM Q13315 ATM serine/threonine kinase kinase; nucleic acid binding; transferase 6.0E-46 0.401 0.862 29
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 1.8E-03 0.352 0.862 22
ERBB3 P21860 erb-b2 receptor tyrosine kinase 3 6.7E-15 0.473 0.690 20
APC P25054 APC, WNT signaling pathway regulator 1.00 0.397 0.828 19
ATR Q13535 ATR serine/threonine kinase kinase; nucleic acid binding; transferase 1.7E-08 0.486 0.759 16
FGFR2 P21802 fibroblast growth factor receptor 2 1.00 0.398 0.759 15
MET P08581 MET proto-oncogene, receptor tyrosine kinase 0.99 0.405 0.793 13
POLE Q07864 DNA polymerase epsilon, catalytic subunit 1.8E-25 0.616 0.345 12
CDH1 P12830 cadherin 1 0.11 0.432 0.759 9
MUTYH Q9UIF7 mutY DNA glycosylase hydrolase; nucleic acid binding 2.7E-17 0.551 0.621 9
AXIN2 Q9Y2T1 axin 2 0.66 0.570 0.552 8
KLF6 Q99612 Kruppel like factor 6 nucleic acid binding; transcription factor 0.98 0.534 0.690 8
UBR5 O95071 ubiquitin protein ligase E3 component n-recognin 5 1.00 0.667 0.483 8
CASP10 Q92851 caspase 10 enzyme modulator; hydrolase; protease 5.2E-12 0.561 0.517 7
IRF1 P10914 interferon regulatory factor 1 nucleic acid binding; transcription factor 0.99 0.503 0.724 6