Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 334
SOD2 P04179 superoxide dismutase 2 Enzyme 0.15 0.379 0.923 280
IL6 P05231 interleukin 6 0.32 0.248 0.962 262
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 234
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 224
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 185
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 178
HMOX1 P09601 heme oxygenase 1 9.7E-03 0.381 0.923 135
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 135
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 128
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 127
ALB P02768 albumin Transporter 0.64 0.317 0.962 122
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 109
PLAU P00749 plasminogen activator, urokinase Enzyme 2.3E-06 0.425 0.923 109
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 103
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 99
GSTP1 P09211 glutathione S-transferase pi 1 1.4E-02 0.383 0.923 98
AHR P35869 aryl hydrocarbon receptor Transcription factor 1.00 0.410 0.923 97
BAP1 Q92560 BRCA1 associated protein 1 Enzyme 0.99 0.454 0.731 97
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 97
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 96
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 90
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 89
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 86