Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TP53 P04637 tumor protein p53 transcription factor 0.17 0.251 0.897 63 218
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha kinase; transferase 1.00 0.341 0.897 54 50
FGFR2 P21802 fibroblast growth factor receptor 2 1.00 0.398 0.759 53 57
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase 1.00 0.352 0.793 52 72
HRAS P01112 HRas proto-oncogene, GTPase enzyme modulator 8.7E-02 0.404 0.828 40 20
KRAS P01116 KRAS proto-oncogene, GTPase enzyme modulator 9.0E-04 0.350 0.724 37 33
NRAS P01111 NRAS proto-oncogene, GTPase enzyme modulator 0.53 0.420 0.690 36 14
PTEN P60484 phosphatase and tensin homolog hydrolase; phosphatase 0.82 0.334 0.828 32 230
CTNNB1 P35222 catenin beta 1 1.00 0.417 0.759 29 32
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 1.8E-03 0.352 0.862 22 26
FBXW7 Q969H0 F-box and WD repeat domain containing 7 enzyme modulator 1.00 0.511 0.759 17 7
MAP2K1 Q02750 mitogen-activated protein kinase kinase 1 0.91 0.459 0.759 15 29
MTOR P42345 mechanistic target of rapamycin kinase kinase; nucleic acid binding; transferase 1.00 0.399 0.793 13 17
SOS1 Q07889 SOS Ras/Rac guanine nucleotide exchange factor 1 enzyme modulator 1.00 0.536 0.655 11 24
PIK3R1 P27986 phosphoinositide-3-kinase regulatory subunit 1 enzyme modulator 1.00 0.515 0.793 11 20
ERBB3 P21860 erb-b2 receptor tyrosine kinase 3 6.7E-15 0.473 0.690 11 7
POLE Q07864 DNA polymerase epsilon, catalytic subunit 1.8E-25 0.616 0.345 10 6
PPP2R1A P30153 protein phosphatase 2 scaffold subunit Aalpha hydrolase; phosphatase 0.99 0.590 0.517 10 5
NFE2L2 Q16236 nuclear factor, erythroid 2 like 2 cytoskeletal protein; hydrolase; nucleic acid binding; transcription factor 3.5E-03 0.420 0.862 8 5
U2AF1 P0DN76 Q01081 U2 small nuclear RNA auxiliary factor 1 nucleic acid binding 0.99 0.624 0.552 8 2
MYCN P04198 MYCN proto-oncogene, bHLH transcription factor nucleic acid binding; transcription factor 0.89 0.481 0.759 7 11
RAC1 P63000 Rac family small GTPase 1 enzyme modulator 0.71 0.470 0.931 5 2
XPO1 O14980 exportin 1 receptor 1.00 0.586 0.655 5 2
RHEB Q15382 Ras homolog, mTORC1 binding enzyme modulator 0.98 0.696 0.379 4 2