| BRAF |
P15056
|
B-Raf proto-oncogene, serine/threonine kinase
|
Kinase
|
1.00 |
0.319 |
0.846 |
125
|
84 |
| PTEN |
P60484
|
phosphatase and tensin homolog
|
Enzyme
|
0.26 |
0.305 |
0.923 |
107
|
343 |
| MTOR |
P42345
|
mechanistic target of rapamycin kinase
|
Kinase
|
1.00 |
0.343 |
0.885 |
86
|
26 |
| PIK3CA |
P42336
|
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
|
Kinase
|
1.00 |
0.292 |
0.923 |
85
|
55 |
| TP53 |
P04637
|
tumor protein p53
|
Transcription factor
|
0.53 |
0.236 |
0.962 |
84
|
390 |
| FGFR2 |
P21802
|
fibroblast growth factor receptor 2
|
Kinase
|
1.00 |
0.380 |
0.808 |
82
|
76 |
| HRAS |
P01112
|
HRas proto-oncogene, GTPase
|
Enzyme modulator
|
8.0E-02 |
0.378 |
0.885 |
71
|
21 |
| CTNNB1 |
P35222
|
catenin beta 1
|
|
1.00 |
0.303 |
0.885 |
70
|
52 |
| KRAS |
P01116
|
KRAS proto-oncogene, GTPase
|
Enzyme modulator
|
7.9E-04 |
0.320 |
0.923 |
66
|
35 |
| SOS1 |
Q07889
|
SOS Ras/Rac guanine nucleotide exchange factor 1
|
Enzyme modulator
|
1.00 |
0.485 |
0.808 |
62
|
28 |
| NRAS |
P01111
|
NRAS proto-oncogene, GTPase
|
Enzyme modulator
|
0.49 |
0.390 |
0.808 |
37
|
14 |
| MAP2K1 |
Q02750
|
mitogen-activated protein kinase kinase 1
|
Kinase
|
0.90 |
0.439 |
0.846 |
26
|
30 |
| PPP2R1A |
P30153
|
protein phosphatase 2 scaffold subunit Aalpha
|
Enzyme
|
0.98 |
0.588 |
0.577 |
26
|
6 |
| ERBB2 |
P04626
|
erb-b2 receptor tyrosine kinase 2
|
Kinase
|
6.0E-03 |
0.328 |
0.923 |
23
|
28 |
| MYCN |
P04198
|
MYCN proto-oncogene, bHLH transcription factor
|
Transcription factor
|
0.89 |
0.454 |
0.808 |
18
|
14 |
| FBXW7 |
Q969H0
|
F-box and WD repeat domain containing 7
|
Enzyme modulator
|
1.00 |
0.465 |
0.808 |
18
|
7 |
| ERBB3 |
P21860
|
erb-b2 receptor tyrosine kinase 3
|
Kinase
|
1.7E-15 |
0.448 |
0.808 |
12
|
7 |
| PIK3R1 |
P27986
|
phosphoinositide-3-kinase regulatory subunit 1
|
Kinase
|
1.00 |
0.477 |
0.885 |
10
|
24 |
| POLE |
Q07864
|
DNA polymerase epsilon, catalytic subunit
|
|
8.0E-27 |
0.526 |
0.731 |
10
|
9 |
| NFE2L2 |
Q16236
|
nuclear factor, erythroid 2 like 2
|
Enzyme
|
3.6E-03 |
0.357 |
0.885 |
10
|
8 |
| MYCNOS |
P40205
|
MYCN opposite strand
|
|
|
0.700 |
0.462 |
9
|
5 |
| U2AF1 |
P0DN76 Q01081
|
U2 small nuclear RNA auxiliary factor 1
|
Nucleic acid binding
|
0.99 |
0.604 |
0.577 |
9
|
2 |
| RHEB |
Q15382
|
Ras homolog, mTORC1 binding
|
Enzyme modulator
|
0.98 |
0.631 |
0.577 |
6
|
3 |
| RAC1 |
P63000
|
Rac family small GTPase 1
|
Enzyme modulator
|
0.76 |
0.429 |
0.962 |
5
|
7 |