Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 oxidoreductase 1.00 0.338 0.897 41
IL10 P22301 interleukin 10 6.5E-03 0.320 0.931 36
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha nucleic acid binding; transcription factor 0.97 0.367 0.793 20
C3 P01024 complement C3 defense/immunity protein; enzyme modulator; signaling molecule 0.94 0.484 0.828 19
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.38 0.321 0.828 17
XDH P47989 xanthine dehydrogenase oxidoreductase 5.0E-22 0.567 0.655 17
G6PD P11413 glucose-6-phosphate dehydrogenase oxidoreductase 0.94 0.476 0.724 16
MET P08581 MET proto-oncogene, receptor tyrosine kinase 0.99 0.405 0.793 15
ABCC3 O15438 ATP binding cassette subfamily C member 3 transporter 7.4E-27 0.542 0.690 12
CTSB P07858 cathepsin B enzyme modulator; hydrolase; protease 3.3E-11 0.490 0.828 12
ABCB1 P08183 ATP binding cassette subfamily B member 1 hydrolase; protease 1.3E-05 0.371 0.828 10
GJB2 P29033 gap junction protein beta 2 cell junction protein 6.5E-16 0.484 0.690 10
PCNA P12004 proliferating cell nuclear antigen nucleic acid binding 0.98 0.417 0.759 10
AKR1B1 P15121 aldo-keto reductase family 1 member B oxidoreductase 1.5E-04 0.536 0.621 9
IGF2 P01344 insulin like growth factor 2 4.7E-02 0.399 0.828 9
MYC P01106 MYC proto-oncogene, bHLH transcription factor nucleic acid binding; transcription factor 1.00 0.382 0.724 9
TGFBR2 P37173 transforming growth factor beta receptor 2 kinase; receptor; transferase 0.15 0.437 0.793 9
A2M P01023 alpha-2-macroglobulin defense/immunity protein; enzyme modulator; signaling molecule 5.6E-11 0.564 0.724 8
CTSL P07711 cathepsin L enzyme modulator; hydrolase; protease 7.7E-03 0.518 0.655 7
DNMT1 P26358 DNA methyltransferase 1 1.00 0.438 0.759 7
ENG P17813 endoglin 1.00 0.477 0.655 7
EP300 Q09472 E1A binding protein p300 nucleic acid binding; transcription factor; transferase 1.00 0.489 0.828 7
MECP2 P51608 methyl-CpG binding protein 2 nucleic acid binding; transferase 0.78 0.463 0.862 7
SMAD4 Q13485 SMAD family member 4 transcription factor 1.00 0.430 0.759 7