Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
EGFR P00533 epidermal growth factor receptor 0.50 0.325 0.862 28
PTEN P60484 phosphatase and tensin homolog hydrolase; phosphatase 0.82 0.334 0.828 27
CTNNB1 P35222 catenin beta 1 1.00 0.417 0.759 23
ATR Q13535 ATR serine/threonine kinase kinase; nucleic acid binding; transferase 1.7E-08 0.486 0.759 16
FGFR2 P21802 fibroblast growth factor receptor 2 1.00 0.398 0.759 15
MLH1 P40692 mutL homolog 1 nucleic acid binding 5.1E-05 0.424 0.759 14
PMS2 P54278 PMS1 homolog 2, mismatch repair system component nucleic acid binding 1.2E-27 0.526 0.586 12
POLE Q07864 DNA polymerase epsilon, catalytic subunit 1.8E-25 0.616 0.345 12
MSH2 P43246 mutS homolog 2 nucleic acid binding 0.91 0.437 0.690 10
MSH6 P52701 mutS homolog 6 2.2E-05 0.495 0.586 10
CUX1 P39880 Q13948 cut like homeobox 1 nucleic acid binding; transcription factor 1.00 0.520 0.655 9
AXIN1 O15169 axin 1 0.73 0.600 0.483 8
PMS1 P54277 PMS1 homolog 1, mismatch repair system component nucleic acid binding 1.5E-16 0.600 0.552 8
RAD21 O60216 RAD21 cohesin complex component 1.00 0.559 0.759 8
MAX P61244 MYC associated factor X nucleic acid binding; transcription factor 0.85 0.604 0.586 6
FBXW7 Q969H0 F-box and WD repeat domain containing 7 enzyme modulator 1.00 0.511 0.759 5
PIK3R2 O00459 phosphoinositide-3-kinase regulatory subunit 2 enzyme modulator 1.3E-02 0.594 0.655 4
SPOP O43791 speckle type BTB/POZ protein 1.00 0.656 0.207 4