Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
LMNA P02545 lamin A/C 1.00 0.406 0.724 483
FGFR2 P21802 fibroblast growth factor receptor 2 1.00 0.398 0.759 374
FLNA P21333 filamin A 1.00 0.456 0.793 361
KRAS P01116 KRAS proto-oncogene, GTPase enzyme modulator 9.0E-04 0.350 0.724 341
FGFR3 P22607 fibroblast growth factor receptor 3 1.8E-05 0.417 0.759 312
FGFR1 P11362 fibroblast growth factor receptor 1 1.00 0.388 0.759 307
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase 1.00 0.352 0.793 303
PTEN P60484 phosphatase and tensin homolog hydrolase; phosphatase 0.82 0.334 0.828 243
PEX1 O43933 peroxisomal biogenesis factor 1 3.3E-14 0.554 0.655 225
EP300 Q09472 E1A binding protein p300 nucleic acid binding; transcription factor; transferase 1.00 0.489 0.828 209
PEX5 P50542 peroxisomal biogenesis factor 5 membrane traffic protein; receptor 1.1E-04 0.555 0.690 202
HRAS P01112 HRas proto-oncogene, GTPase enzyme modulator 8.7E-02 0.404 0.828 199
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha kinase; transferase 1.00 0.341 0.897 199
PRKAR1A P10644 protein kinase cAMP-dependent type I regulatory subunit alpha 1.00 0.466 0.690 199
POLG P54098 DNA polymerase gamma, catalytic subunit nucleic acid binding; transferase 1.3E-09 0.477 0.724 194
MED12 Q93074 mediator complex subunit 12 nucleic acid binding; transcription factor 1.00 0.528 0.655 192
GBA P04062 glucosylceramidase beta 5.6E-06 0.521 0.724 188
FIG4 Q92562 FIG4 phosphoinositide 5-phosphatase 3.3E-34 0.561 0.655 185
RNU4ATAC RNA, U4atac small nuclear (U12-dependent splicing) 0.577 0.655 184
MECP2 P51608 methyl-CpG binding protein 2 nucleic acid binding; transferase 0.78 0.463 0.862 182
PEX2 P28328 peroxisomal biogenesis factor 2 2.8E-04 0.575 0.621 182
PIEZO2 Q9H5I5 piezo type mechanosensitive ion channel component 2 2.3E-06 0.573 0.655 173
AKT1 P31749 AKT serine/threonine kinase 1 calcium-binding protein; kinase; transfer/carrier protein; transferase 0.98 0.355 0.862 172
OFD1 O75665 OFD1, centriole and centriolar satellite protein 0.97 0.547 0.724 172