Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
MMP9 P14780 matrix metallopeptidase 9 hydrolase; protease 7.0E-18 0.339 0.862 60
IL1B P01584 interleukin 1 beta 0.13 0.312 0.931 57
TNF P01375 tumor necrosis factor signaling molecule 0.80 0.263 0.966 48
BCL2 P10415 BCL2, apoptosis regulator signaling molecule 0.57 0.312 0.862 43
ACE P12821 angiotensin I converting enzyme hydrolase; protease 1.6E-37 0.367 0.897 42
HMOX1 P09601 heme oxygenase 1 oxidoreductase 7.9E-03 0.403 0.862 36
NOS2 P35228 nitric oxide synthase 2 1.5E-14 0.385 0.931 36
AGER Q15109 advanced glycosylation end-product specific receptor cell adhesion molecule; receptor 3.4E-16 0.472 0.724 33
SERPINE1 P05121 serpin family E member 1 enzyme modulator 4.7E-02 0.384 0.793 31
BAX Q07812 BCL2 associated X, apoptosis regulator signaling molecule 0.30 0.450 0.862 29
BECN1 Q14457 beclin 1 enzyme modulator 0.91 0.497 0.759 27
MTOR P42345 mechanistic target of rapamycin kinase kinase; nucleic acid binding; transferase 1.00 0.399 0.793 27
AGT P01019 angiotensinogen enzyme modulator 3.9E-08 0.406 0.862 25
NQO1 P15559 NAD(P)H quinone dehydrogenase 1 1.0E-09 0.467 0.724 23
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha nucleic acid binding; transcription factor 0.97 0.367 0.793 20
NGFR P08138 nerve growth factor receptor receptor 0.30 0.508 0.724 20
APOE P02649 apolipoprotein E 1.7E-03 0.352 0.931 19
C3 P01024 complement C3 defense/immunity protein; enzyme modulator; signaling molecule 0.94 0.484 0.828 19
BDNF P23560 brain derived neurotrophic factor signaling molecule 0.70 0.382 0.828 18
IL4 P05112 interleukin 4 5.3E-03 0.364 0.931 18
BAD Q92934 BCL2 associated agonist of cell death 4.9E-03 0.579 0.552 17
AQP4 P55087 aquaporin 4 transporter 2.8E-03 0.525 0.793 16
CASP3 P42574 caspase 3 enzyme modulator; hydrolase; protease 0.28 0.391 0.862 16
HP P00738 haptoglobin hydrolase; protease 7.4E-05 0.461 0.793 15