Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase 1.00 0.352 0.793 45
TP53 P04637 tumor protein p53 transcription factor 0.17 0.251 0.897 39
KRAS P01116 KRAS proto-oncogene, GTPase enzyme modulator 9.0E-04 0.350 0.724 33
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha kinase; transferase 1.00 0.341 0.897 33
ATM Q13315 ATM serine/threonine kinase kinase; nucleic acid binding; transferase 6.0E-46 0.401 0.862 29
HRAS P01112 HRas proto-oncogene, GTPase enzyme modulator 8.7E-02 0.404 0.828 29
PTEN P60484 phosphatase and tensin homolog hydrolase; phosphatase 0.82 0.334 0.828 27
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 1.8E-03 0.352 0.862 22
AKT1 P31749 AKT serine/threonine kinase 1 calcium-binding protein; kinase; transfer/carrier protein; transferase 0.98 0.355 0.862 20
BRCA2 P51587 BRCA2, DNA repair associated nucleic acid binding 5.5E-24 0.426 0.793 17
NOTCH1 P46531 notch 1 1.00 0.415 0.759 16
AKT2 P31751 AKT serine/threonine kinase 2 calcium-binding protein; kinase; transfer/carrier protein; transferase 0.61 0.512 0.655 15
NOTCH2 Q04721 notch 2 1.00 0.474 0.724 15
BAP1 Q92560 BRCA1 associated protein 1 hydrolase; protease 0.99 0.488 0.586 14
BRCA1 P38398 BRCA1, DNA repair associated ligase 1.8E-28 0.410 0.862 14
PALB2 Q86YC2 partner and localizer of BRCA2 7.3E-20 0.569 0.552 13
RB1 P06400 RB transcriptional corepressor 1 nucleic acid binding; transcription factor 1.00 0.467 0.828 13
EP300 Q09472 E1A binding protein p300 nucleic acid binding; transcription factor; transferase 1.00 0.489 0.828 12
BRIP1 Q9BX63 BRCA1 interacting protein C-terminal helicase 1 nucleic acid binding 4.8E-17 0.586 0.552 11
CHEK2 O96017 checkpoint kinase 2 1.2E-23 0.494 0.621 10
ESR1 P03372 estrogen receptor 1 nucleic acid binding; receptor; transcription factor 1.00 0.355 0.897 10
BARD1 Q99728 BRCA1 associated RING domain 1 2.2E-24 0.624 0.379 9
FGFR1 P11362 fibroblast growth factor receptor 1 1.00 0.388 0.759 9
MAP2K4 P45985 mitogen-activated protein kinase kinase 4 1.00 0.582 0.586 9