Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor signaling molecule 0.80 0.263 0.966 343 7
SOD2 P04179 superoxide dismutase 2 oxidoreductase 0.16 0.396 0.897 290 0
IL6 P05231 interleukin 6 0.34 0.287 0.966 271 3
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 oxidoreductase 1.00 0.338 0.897 243 0
IL1B P01584 interleukin 1 beta 0.13 0.312 0.931 236 1
MTHFR P42898 methylenetetrahydrofolate reductase 1.2E-09 0.354 0.828 195 82
IFNA2 P01563 interferon alpha 2 0.459 0.793 172 0
CSF3 P09919 colony stimulating factor 3 0.33 0.421 0.828 169 1
IFNG P01579 interferon gamma 0.47 0.323 0.897 167 0
CAT P04040 catalase oxidoreductase 1.9E-10 0.397 0.828 166 1
SOD1 P00441 superoxide dismutase 1 oxidoreductase 0.13 0.406 0.931 156 35
HMOX1 P09601 heme oxygenase 1 oxidoreductase 7.9E-03 0.403 0.862 140 3
PLAT P00750 plasminogen activator, tissue type hydrolase; protease 3.5E-05 0.459 0.828 138 0
CCL2 P13500 C-C motif chemokine ligand 2 signaling molecule 0.62 0.353 0.897 138 0
CTNNB1 P35222 catenin beta 1 1.00 0.417 0.759 123 33
APOE P02649 apolipoprotein E 1.7E-03 0.352 0.931 121 22
ALB P02768 albumin transfer/carrier protein 0.61 0.412 0.828 118 7
IGF1 P05019 insulin like growth factor 1 0.29 0.355 0.828 110 8
PON1 P27169 paraoxonase 1 9.0E-11 0.443 0.828 110 5
GSTP1 P09211 glutathione S-transferase pi 1 7.1E-02 0.406 0.828 102 2
AHR P35869 aryl hydrocarbon receptor receptor; transcription factor 1.00 0.462 0.862 89 0
MMP2 P08253 matrix metallopeptidase 2 hydrolase; protease 0.84 0.373 0.862 88 9
ABCB1 P08183 ATP binding cassette subfamily B member 1 hydrolase; protease 1.3E-05 0.371 0.828 86 3
POLG P54098 DNA polymerase gamma, catalytic subunit nucleic acid binding; transferase 1.3E-09 0.477 0.724 84 50