Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
STK11 Q15831 serine/threonine kinase 11 Kinase 0.99 0.435 0.808 12 18
TP63 Q9H3D4 tumor protein p63 Transcription factor 1.00 0.362 0.769 11 17
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 10 32
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 10 29
CDH1 P12830 cadherin 1 0.15 0.401 0.808 10 8
BRCA2 P51587 BRCA2 DNA repair associated Nucleic acid binding 2.4E-25 0.379 0.846 8 78
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 7 13
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923 5 98
MRE11 P49959 MRE11 homolog, double strand break repair nuclease 1.3E-12 0.527 0.808 4 5
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 4 4
BRIP1 Q9BX63 BRCA1 interacting protein C-terminal helicase 1 Enzyme 6.2E-17 0.507 0.731 3 5
DPH1 Q9BZG8 diphthamide biosynthesis 1 8.0E-17 0.653 0.538 2 4
RRAS2 P62070 RAS related 2 Enzyme modulator 0.97 0.656 0.500 1 1
OPCML Q14982 opioid binding protein/cell adhesion molecule like 0.23 0.606 0.654 1 1
FAM107A O95990 family with sequence similarity 107 member A 8.3E-07 0.674 0.462 1 0