Source: CGI

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 45
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 39
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 33
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 33
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 29
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 28
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 27
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 23
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 22
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 20
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885 20
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 18
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808 17
AKT2 P31751 AKT serine/threonine kinase 2 Kinase 0.64 0.474 0.769 15
FGFR3 P22607 fibroblast growth factor receptor 3 Kinase 1.6E-05 0.391 0.846 14
MET P08581 MET proto-oncogene, receptor tyrosine kinase Kinase 0.97 0.380 0.846 13
EP300 Q09472 E1A binding protein p300 1.00 0.459 0.846 12
MLH1 P40692 mutL homolog 1 Nucleic acid binding 3.4E-05 0.399 0.808 12
POLE Q07864 DNA polymerase epsilon, catalytic subunit 8.0E-27 0.526 0.731 12
MAP2K1 Q02750 mitogen-activated protein kinase kinase 1 Kinase 0.90 0.439 0.846 10
PMS2 P54278 PMS1 homolog 2, mismatch repair system component Nucleic acid binding 4.5E-27 0.484 0.808 10
RNF43 Q68DV7 ring finger protein 43 0.73 0.584 0.577 10
CUX1 P39880 Q13948 cut like homeobox 1 Transcription factor 1.00 0.465 0.846 9
MAP2K4 P45985 mitogen-activated protein kinase kinase 4 Kinase 1.00 0.559 0.692 9