Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 340 9
SOD2 P04179 superoxide dismutase 2 Enzyme 0.15 0.379 0.923 285 1
IL6 P05231 interleukin 6 0.32 0.248 0.962 270 4
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 239 0
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 232 407
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 231 5
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 192 93
NOS2 P35228 nitric oxide synthase 2 4.0E-15 0.364 0.923 184 9
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 182 355
CAT P04040 catalase Enzyme 1.6E-10 0.359 0.962 171 2
CSF3 P09919 colony stimulating factor 3 0.38 0.377 0.885 168 2
IFNG P01579 interferon gamma 0.47 0.288 0.962 167 1
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 164 35
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 141 11
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 138 40
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 138 9
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 138 5
HMOX1 P09601 heme oxygenase 1 9.7E-03 0.381 0.923 137 3
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 130 54
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 124 58
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 120 21
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 119 12
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 115 105
LEP P41159 leptin 0.46 0.349 0.846 114 3