Source: INFERRED

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 382
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 342
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 341
MECP2 P51608 methyl-CpG binding protein 2 Epigenetic regulator 0.89 0.414 0.846 326
PTPN11 Q06124 protein tyrosine phosphatase non-receptor type 11 1.00 0.385 0.923 286
PTCH1 Q13635 patched 1 1.00 0.398 0.885 262
ATRX P46100 ATRX chromatin remodeler 1.00 0.452 0.808 236
GNAS O95467 P63092 P84996 Q5JWF2 GNAS complex locus Enzyme modulator 0.68 0.420 0.885 232
GJA1 P17302 gap junction protein alpha 1 Cell-cell junction 0.16 0.393 0.885 224
MED12 Q93074 mediator complex subunit 12 Transcription factor 1.00 0.476 0.769 216
KMT2A Q03164 lysine methyltransferase 2A 1.00 0.410 0.885 205
ARID1B Q8NFD5 AT-rich interaction domain 1B 1.00 0.503 0.846 200
POLR3A O14802 RNA polymerase III subunit A Enzyme 1.3E-23 0.538 0.769 198
TMEM67 Q5HYA8 transmembrane protein 67 2.1E-24 0.512 0.769 182
SMC1A Q14683 structural maintenance of chromosomes 1A 1.00 0.509 0.808 174
TBC1D24 Q9ULP9 TBC1 domain family member 24 Enzyme modulator 1.3E-08 0.530 0.808 172
NIPBL Q6KC79 NIPBL cohesin loading factor Nucleic acid binding 1.00 0.521 0.808 169
TCF4 P15884 transcription factor 4 Transcription factor 1.00 0.464 0.846 165
CACNA1A O00555 calcium voltage-gated channel subunit alpha1 A Ion channel 1.00 0.489 0.769 163
HDAC8 Q9BY41 histone deacetylase 8 Epigenetic regulator 0.98 0.511 0.885 161
KIF7 Q2M1P5 kinesin family member 7 2.3E-22 0.528 0.731 161
EP300 Q09472 E1A binding protein p300 1.00 0.459 0.846 160
IFIH1 Q9BYX4 interferon induced with helicase C domain 1 7.0E-44 0.471 0.808 158
NAA10 P41227 N-alpha-acetyltransferase 10, NatA catalytic subunit Enzyme 0.76 0.535 0.692 156